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PhD Student (f/m) in Molecular Medicine

Universitätsklinikum Jena. Jena, 12.07.2017

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The Integrated Research Training Group of PolyTarget at the Jena University Hospital invites applications for the position

PhD Student (m/f) in Molecular Medicine

Selective targeting of hepatocytes using
multifunctional block copolymer micelles to
restore critical cellular signaling functions

The goal of this project is to develop methods that allow targeting micelles to hepatocytes avoiding circulating and neighboring immunocompetent cells in health and infectious diseases to interfere with critical cellular kinase signaling and prevent liver failure.
To achieve this goal double hydrophilic block copolymers containing one cationic segment are developed and investigated to realize anti-sense strategies aiming to disrupt kinase signaling in vitro and in vivo. The synthesis part will be guided by polymer chemists providing need materials while here the nanophysiology of the carriers and the molecular biology of cholestasis are in focus.
Requirements:
  • A Master’s degree (or equivalent) in e.g. material sciences, (molecular) biology, life sciences, molecular medicine, biochemistry, pharmacology or a related discipline; candidates expected to earn their degree before September 2017 are welcome to apply
  • Solid knowledge of molecular biology, biochemistry and physiology are preferred alongside with good understanding of (polymer) chemistry and nanotechnology
  • Excellent technical skills in e.g.: molecular biology, biophotonics / microscopy, and cell biology and willingness to interdisciplinary combine knowledge about cell biology and nanotechnology, FELASA-B qualification is preferred
  • Readiness to collaborate with short timescale work in the field and accompany implementation
  • Enthusiasm to play an active role in the interdisciplinary research team of PolyTarget
  • Highly motivated and creative personalities, with an interest to shape their own thesis project
  • Excellent written and oral communications skills in English
Start your career at Jena University Hospital! We look forward to receiving your application. Please send it via our online application tool on www.uniklinikum-jena.de/Karriere
The Collaborative Research Center 1278 "PolyTarget - Polymer-based nanoparticle libraries for targeted anti-inflammatory strategies" will be funded by the Deutsche Forschungsgemeinschaft (DFG). The goal of PolyTarget is to develop polymer-based, nanoparticulate carrier materials for pharmaceutically active ingredients for targeted therapy of diseases and syndromes, whose morbidity is characterized by an inflammatory reaction. The integrated Research Training Group of PolyTarget is educating doctoral researchers in a structured, interdisciplinary training program. Close cooperation within the multi- and interdisciplinary consortium with researchers from Chemistry, Materials Science, Biology, Pharmacy and Medicine offers unique prerequisites for transferring the findings from basic research into applications.
We offer:
  • A doctoral researcher position (TV-L E13 – salary agreement for public service employees, 65%) with funding from Sep. 1st, 2017, until Jun 30th, 2021, as well as generous research funding
  • Opportunity for research on an innovative and worldwide unique research platform
  • A comprehensive mentoring program with supervision by a team of advisors
  • A communicative atmosphere within a scientific network providing top-level research facilities and training program, including participation in international and national conferences, summer schools and workshops
  • The place of work is Jena, Germany, a young and lively university town with dynamic business activities, successful scientific centers of innovation, and a vibrant cultural scene around an university with a rich tradition
Reference number: DM21/2017
Application deadline: 30.07.2017
In case of equal qualification, persons with disabilities will be given priority.
Contact:
Prof. Dr. Michael Bauer
Klinikdirektor
Tel. 03641 – 9323101
Universitätsklinikum Jena
Am Klinikum 1 | 07747 Jena



Bewerbungsschluss: 30.07.2017