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PhD Student (f/m)

Deutsches Herzzentrum München an der Technischen Universität München. München, 13.06.2017

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The German Heart Center of the Free State of Bavaria associated to the Technical University of Munich is a clinic with international reputation and a state of the art technical and medical equipment.

The laboratory of cardiovascular inflammation at the Department of Cardiovascular Diseases (Director: Prof. D. Heribert Schunkert) is seeking a

PhD student (m/f)
(Promotionsstelle)

Position:
We are looking to recruit a highly-motivated PhD student to join a dynamic research team at the German Heart Center Munich, department of cardiology. Our research focusses on the role of the immune system in cardiovascular disease. Specifically, we are interested in the origin, function and fate of innate immune cells (monocytes, macrophages, neutrophils) in atherosclerosis and wound healing after myocardial infarction. Based on new mechanistic understanding, we seek to develop novel therapeutic concepts. We are part of the German Heart Center Munich and aim translate our findings to better understand and improve human health. We are funded by "Deutsche For­schungs­ge­mein­schaft", "Deutsches Zentrum für Herz-Kreislauf-Forschung", "Else-Kröner-Fresenius-Stiftung" and "Deutsche Herzstiftung".

Requirements:
The successful applicant should have an excellent command of flow cytometry techniques, in addition to standard molecular biology.

Your application should include:
  • Cover letter describing your research interest and why you are suitable for the position (maximum 1 page)
  • CV including a list of relevant publications
  • Copy of the official academic transcript of your degree or a letter stating when your degree will be obtained
  • Names, e-mail addresses, and telephone numbers for academic references/recommendation letters
Recent publications:
Proliferation and Recruitment Contribute to Myocardial Macrophage Expansion in Chronic Heart Failure.
Sager HB, Hulsmans M, Lavine KJ, Beltrami Moreira MB, Heidt T, Courties G, Sun Y, Iwamoto Y, Tricot B, Khan OF, Dahlman JE, Borodovsky A, Fitzgerald K, Anderson DG, Weissleder R, Libby P, Swirski FK, Nahrendorf M. Circ Res. 2016 Sep 16;119(7):853-64. doi: 10.1161/CIRCRESAHA.116.309001. (IF=11.6)

RNAi targeting multiple cell adhesion molecules reduces immune cell recruitment and vascular inflammation after myocardial infarction.
Sager HB, Dutta P, Dahlman JE, Hulsmans M, Courties G, Sun Y, Heidt T, Vinegoni C, Borodovsky A, Fitzgerald K, Wojtkiewicz GR, Iwamoto Y, Tricot B, Khan OF, Kauffman KJ, Xing Y, Shaw TE, Libby P, Langer R, Weissleder R, Swirski FK, Anderson DG, Nahrendorf M.
Sci Transl Med. 2016 Jun 8;8(342):342ra80. doi: 10.1126/scitranslmed.aaf1435. (IF=16.3)

Targeting Interleukin-1ß Reduces Leukocyte Production After Acute Myocardial Infarction.
Sager HB, Heidt T, Hulsmans M, Dutta P, Courties G, Sebas M, Wojtkiewicz GR, Tricot B, Iwamoto Y, Sun Y, Weissleder R, Libby P, Swirski FK, Nahrendorf M.
Circulation. 2015 Nov 17;132(20):1880-90. doi: 10.1161/CIRCULATIONAHA.115.016160. (IF=17)

Myocardial Infarction Activates CCR2(+) Hematopoietic Stem and Progenitor Cells.
Dutta P*, Sager HB* (contributed equally), Stengel KR, Naxerova K, Courties G, Saez B, Silberstein L, Heidt T, Sebas M, Sun Y, Wojtkiewicz G, Feruglio PF, King K, Baker JN, van der Laan AM, Borodovsky A, Fitzgerald K, Hulsmans M, Hoyer F, Iwamoto Y, Vinegoni C, Brown D, Di Carli M, Libby P, Hiebert SW, Scadden DT, Swirski FK, Weissleder R, Nahrendorf M. Cell Stem Cell. 2015 May 7;16(5):477-87. doi: 10.1016/j.stem.2015.04.008. (IF=22.4)

Chronic variable stress activates hematopoietic stem cells.
Heidt T*, Sager HB* (contributed equally), Courties G, Dutta P, Iwamoto Y, Zaltsman A, von Zur Muhlen C, Bode C, Fricchione GL, Denninger J, Lin CP, Vinegoni C, Libby P, Swirski FK, Weissleder R, Nahrendorf M. Nat Med. 2014 Jul;20(7):754-8. doi: 10.1038/nm.3589. (IF=27.4)

Our offer:
The position covers a three-year period with possibility of extension, starting as soon as possible. The salary is based on the TV-L (70% German TV-L E13).
The German Heart Center Munich promotes professional equality between women and men and provides the same employment opportunity for severely disabled people in case of equal qualifications.

Contacts:
  • Hendrik Sager, MD, Principal Investigator, telephone ++49 89 1218 2935
  • Thomas Schmid, Head of Recruiting/HR, telephone ++49 89 1218 1734
More informations you find also at our homepage:
http://www.dhm.mhn.de/de/kliniken_und_institute/klinik_fuer_herz-und_kreislauf/wissenschaftliche_arbeitsgrupp/kardiovaskulaere_inflammation.cfm

Please send us your application until July 15th, 2017 by E-Mail to: career@dhm.mhn.de
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Bewerbungsschluss: 15.07.2017