The main focus of the Division of Nephrology of the Department of Internal Medicine III (Head: Prof. Dr. med. Ch. Hugo; ( http://www.nephrologie-dresden.org) is the diagnosis and treatment of renal diseases and hypertension. Nephrology is a division with a lot of research possibilities with national and international collaborations and includes a wide variety of basic and patient-based clinical research. Hereby, we aim to offer medical treatments to our patients which is always based on the latest evidence and to develop innovative therapies by our clinical and translational studies.

As soon as possible, we invite you to apply for a position as

Predoctoral Fellow / PhD student (f/m)

The position is immediately available. The contract is planned for 24 months with a possibility for extension.

Our group focuses on the regenerative mechanisms in the kidney with respect to molecular and cellular interactions of resident and extrinsic cell types. By creating a triple transgenic mouse model, we have recently identified juxtaglomerular renin-positive cells as one important precursor cell type for glomerular regeneration after injury (Starke et al., J Am Soc Nephrol 2015). Future studies will in particular focus on the role of the immune system, inflammatory cytokines, macula densa interactions, and the resident kidney perivascular pericytes in the regulation of this renal precursor cell niche.

We offer a broad spectrum of methods in molecular and cell biology including in vivo gene transfer methods, imaging, and generation of transgenic mice. A large set of mouse models for kidney research is available.

Your profile:
The successful candidate should incorporate into ongoing projects on the identification and characterization of stem and progenitor cell niches participating in the regeneration of the kidney.

The PhD student will be expected to work on the characterization of transgenic mice with compromised signaling mechanisms of innate immunity in progenitor Renin Lineage Cells (RLCs) by IHC, FACS and intravital imaging. The principal aim of the project is to study the interplay between innate immunity and the progenitor RLC niche during mesangial cell regeneration after glomerular injury. The understanding of the molecular mechanisms of this interaction is clinically important for developing specific therapeutic strategies to beneficially influence the processes of kidney repair in chronic kidney disease.

We are looking for highly motivated applicants preferably with experience in handling small laboratory animals pursueing a PhD thesis with translational potential in experimental nephrology/regenerative mechanisms. The ideal candidates hold a FELASA B (or equivalent) certificate.

We offer you:
  • Excellent research field with an excellent basic research scientific campus including the Center for Regenerative Therapies Dresden (CRTD), the Medical Faculty, the BIOTEC and the Max-Planck Institute for Cell Biology and Genetics in close neighbourhood to the historic city of Dresden
  • Arranging for flexible working hours to find a balance between work and family life
  • Using our internal prevention program including courses and fitness in our Carus Vital health center
  • Providing for the future in the form of a company pension plan
Women are explicitly invited to apply. Handicapped persons will be preferred in case of equal qualification.

We kindly ask you to apply preferably via our online form to make the selection process faster and more effective. Of course, we also consider your written application without any disadvantages. A detailed CV (with publications if available), cover letter and the names of two references should be provided.

We look forward to receiving your application, until January 19, 2018, online on our Website www.uniklinikum-dresden.de with registration number MK30917983.

For further information please contact:
Susanne Dollfus – phone 0049-0351-458-4233 or by mail: susanne.dollfus@ukdd.de

Bewerbungsschluss: 19.01.2018