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Postdoc position (f/m) Molecular Biology Research in AML & Sarcoma

University Hospital Heidelberg. Heidelberg, 28.03.2018

The University Hospital Heidelberg is one of the major healthcare centers in Germany. Our objective is the development of innovative diagnostics and therapies as well as their quick implementation for the patient. With about 10,000 employees in more than 50 specialized clinical departments with roughly 1,900 beds, about 66,000 patients in part-time and fulltime inpatient treatment as well as 1,000,000 patients in ambulant treatment are medicated each year.
At the Heidelberg University Hospital, Department of Hematology, Oncology and Rheumatology, we are offering initially for 2 years a

Postdoc position (m/f)

Molecular Biology Research
in AML & Sarcoma

in the research group of Prof. Carsten Müller-Tidow ( in full-time with the option of further extension.
Starting date: as soon as possible.
The successful candidate should have a PhD degree or equivalent with a strong background in hematology, molecular biology and/or cell biology.
The work in our research group focuses on stem cells and therapy resistance. We aim to understand how epigenetic dysregulation participates in the pathogenesis and chemo- resistance of AML. To follow this question a broad number of in-vitro- and in-vivo-models are investigated. The final aim of our studies is to translate the experimental findings into novel treatment strategies for AML patients at diagnosis and relapse.
The postdoctoral fellow will work in a team of enthusiastic biologists and medical scientists with the aim to identify genetic networks in the regulation of human leukemia stem cell activity and to understand the mechanisms of developing and overcoming therapy resistance.
Related Publications:
Göllner, S et al: Loss of the Histone Methyltransferase EZH2 induces Resistance to Multiple Drugs in Acute Myeloid Leukemia (AML). Nature Medicine 2017 Jan;23(1):69-78.
Zhou, F et al: AML1-ETO requires enhanced C/D box snoRNA formation to induce self-renewal and leukemia. Nature Cell Biology, April 2017
Your Profile:
  • PhD in Biology, Biochemistry or equivalent
  • Broad expertise in basic cell-molecular and biochemical techniques (Western blotting, immunoprecipitations, ChIP, gene expression analysis, cloning, cell culture, lentiviral transductions, flow cytometry, microscopy, etc.)
  • Experience and skills in the following techniques: xenotransplantation, mice handling, Next-Generation-Sequencing, CRSPR/CAS9, shRNA-mediated knock down and genome editing techniques
  • Experience and high motivation to work with mice and primary patient cells
  • High motivation to work hard in a competitive research field
  • Drive independently the experimental and project design
  • Rapid understanding and independent analysis of complex data
  • Experience in writing scientific reports and papers
  • Very good knowledge of and experience with Microsoft Office and graphic programs, statistical software, bioinformatics tools and online tools (e.g. Illustrator, Lightroom, GraphPad-Prism, R, BLAST)
  • Strong communication skills (oral presentations and writing)
  • Fluent both in written and spoken English and German
What we offer:
  • A highly dedicated, stimulating, diverse and international team with access to on-site mouse facilities, sequence facilities and unique leukemia samples, where your contribution can have a real impact
  • Access to state-of-the art equipment
  • An exciting and highly translational research field
  • Highly innovative projects within the field of leukemia research
  • Presentation and publication of the data at international scientific meetings and in journals
  • Collaboration with many experimentally or theoretically oriented labs in the university hospital, in the Heidelberg area and with international research partners of other organizations abroad
Additionally we offer:
Individual, target-oriented advanced training, ticket for public transport, health promotion, university sports / library
Applications should be sent by e-mail as one single pdf-file (max 5 MB) to, Science Coordination, Department of Hematology, Oncology, Rheumatology, Heidelberg University Hospital.
Subject reference: Postdoc Science 01-18 – your surname.
Applications should include a CV, cover letter, certificates, expected availability date, a complete list of publications and 2 - 3 references. For further information you may contact: Annette Becker, M.A., Science Coordinator, phone +49(0) 6221-56-8552.
Please do not send original documents by mail services, since they will not be returned.
Heidelberg University Hospital
Department of Hematology, Oncology and Rheumatology
Prof. Dr. C. Müller-Tidow, Medical Director
Im Neuenheimer Feld 410, 69120 Heidelberg
zert The University Hospital Heidelberg offers:

■ individual, target-oriented advanced training ■ ticket for public transport
nursery and kindergarten as well as holiday organization for schoolchildren
information on flat-hunting ■ health promotion ■ university sports / library

We stand for equal opportunities. People with disabilities are given priority with the same suitability. The university hospital aims at a general increase in the proportion of women in all areas and positions where women are underrepresented. Qualified women are therefore particularly encouraged to apply.