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PhD position in neurovascular biology and neurooncology

Klinikum der Universität München / University Clinics Munich / Hospital of the University of Munich. München, 24.05.2018

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The Hospital of the University of Munich, Germany, is one of the largest and most competitive university hospitals in Germany and Europe. 47 specialized hospitals, departments and institutions harbouring excellent research and education provide patient care at the highest medical level with approximately 10.000 employees.
The University Clinics Munich seek applications from highly motivated candidates for a PhD position in neurovascular biology and neurooncology.

PhD Student (m/f)

A PhD-project with secured funding (salary scale according to German Research Foundation guidelines) for three years is available under supervision of PI Rainer Glass; Walter-Brendel-Centre of Experimental Medicine, University Hospital, LMU Munich, Munich, Germany; Neurosurgical Research, University Hospital, LMU Munich, Munich, Germany.
Outline for the future project:
We identified a non-vascular pericyte precursor, which is necessary for vascular-plasticity and vascular-stability during periods of neo-angiogenesis. We have developed several transgenic mouse models to study these cells in vivo by lineage-tracing, linage-ablation and abrogation of their precursor cell-identity. We aim to uncover the biological-role of the pericyte precur­sors in stroke, neurooncology and/or development and will agree with our PhD candidate upon the physiological and pathological background of the project (according to the candi­dates preferences). In addition to morphological and immunohistochemical inspection of brain preparations will use techniques for vessel-isolation, cell-separation and single-cell RNAseq analysis from transgenic mouse brains and can extent our research to the use of human brain specimen.
We invite applications from candidates having a M.Sc. or equivalent degree in biology or biochemistry. Previous experience in vascular research or neuroscience is beneficial. Team spirit, capability of indepen­dent self-motivated work, as well as very good English and communication skills are required.
We are looking for a person willing to intellectually advance the project, to use transgenic mouse-models for neuro­science, to explore brain physiology and pathology by (confocal) microscopy (and immuno­fluorescence), to develop concepts for pharmacological modulation of pericyte precursors and to obtain a sound genetic characterization of our target cell population in order to investigate an new precursor cell-type in the brain.
Application details:
Applications should include a curriculum vitae, certificates and transcripts of academic degrees, a letter of motivation detailing the applicant's research interests, and contact information for two references. The position can be filled immediately.
Please note that in case of transmitting your job application by email your data will not be encrypted and might potentially be noticed or adulterated by unauthorized third parties.
Please send your application within one PDF-document until June 30th to:
Klinikum der Universität München
Walter Brendel Zentrum für Exprimentelle Medizin
Marchioninistrasse 15
81377 Munich, Germany
Email: rainer.glass@med.uni-muenchen.de

Bewerbungsschluss: 30.06.2018