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PhD student (f/m/d) for the research group 'Non-coding RNA in Health and Disease'
University of Würzburg
The Mildred Scheel Early Career Center (MSNZ) for Cancer
Research at the University of Würzburg is funded by the German
Cancer Aid and brings together life scientists and medical doctors
to understand mechanisms of tumour formation and to develop
new therapeutic strategies.
The research group ‘Non-coding RNA in Health and Disease‘
of Kaspar Burger is seeking for a
PhD student (m/f/d)
job code NG1-1019, to investigate the role of Dicer and
double-stranded RNA for tumourigenesis.Project
Apply if you have
The deadline for the application is 2019-11-20.
The RNA interference factor Dicer is a central component of the
microRNA biogenesis pathway in the cytoplasm. In addition, Dicer
processes a number of non-canonical, double-stranded RNA
substrates to modulate gene expression in the nucleus. For
example, nuclear Dicer regulates alternative cleavage and
polyadenylation at a subset of protein-coding genes. In damaged
nuclei, nuclear Dicer promotes the RNA-dependent recognition of
DNA double-strand beaks. Interestingly, heterozygous mutations of
the DICER1 gene lead to a haploinsufficiency phenotype, which is
associated with genomic instability and increased formation of
We aim to understand how the accumulation of aberrant RNA
species becomes pathogenic. The successful candidate will analyse
the impact of non-processed double-stranded RNA on gene
expression in context of the innate immune response by using
state-of-the-art biochemical and cell biological assays.
The newly established research group is located at the Biocenter of
the University of Würzburg, a well-renowned, interdisciplinary
research facility that offers a supportive and stimulating
environment. For further information visit: https://www.biozentrum.uni-wuerzburg.de/en/home/
Full-time appointment, competitive salary (TV-L E13, 65%), fixedterm,
3-year PhD program, hands-on supervision, intellectual support
Modern lab space and access to core facilities
Enrolment in the Graduate School of Life Sciences with broad
training in methods and skills
Close collaborations with the Comprehensive Cancer Center, the
Helmholtz Institute for RNA-based Infection Research, and the
Virchow Center for Experimental Biomedicine
Würzburg is a thriving university town with many bars, local
recreation areas and travel links
Apply if you have
M.Sc. or an equivalent qualification in Biology, Biochemistry, or a
Strong interest in RNA biology, innate immunity, and genome
Experience with tissue culture and standard molecular biology
Experience in next-generation sequencing or CLIP experiments
The working language is English, knowledge of the German
language is not required
To apply, please submit your CV with references and a 1-page letter
of motivation as single .pdf file via email. Prior publications or
international experience are welcome, but no prerequisite.
The deadline for the application is 2019-11-20. Interviews will
be held as soon as possible thereafter.
The University of Würzburg is an equal opportunities employer. We
encourage women to apply. Applications of people with special
needs are particularly welcome.
Please contact: Dr. Martin Czolbe, MSNZ
Josef-Schneider-Str. 2, 97080 Würzburg, Germany
Phone: +49 931 201-56439
E-Mail: Czolbe_m@ukw.de www.ukw.de