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PhD Student Position (f/m/d) in a research project analyzing the communication between neutrophilic granulocytes and other cells of the innate and adaptive immune system
Universitätsmedizin Göttingen (UMG)
The Clinic for Dermatology, Venereology and Allergology offers as soon as possible a
PhD student position (f/m/d)
in a research project analyzing the
communication between neutrophilic
granulocytes and other cells of the innate and
adaptive immune system
limited to 3 years, 19.25 h/week (50%) | salary according to TV-L
The University Medical Center Göttingen is a tertiary care center and offers great development potential. Its 7,700 employees work in over
65 departments and facilities to provide top quality patient care, excellent research, and modern teaching. Located near the center of Germany,
the University Medical Center Göttingen is based in the “City of Science” and embedded in the city’s attractive network
of scientific research facilities
Cells of the innate immune system communicate with each other and with cells of the adaptive immune system to orchestrate immunologic responses.
Communication between cells influences important cellular functions, such as apoptosis, production of neutrophil extracellular traps (NETs), and
collective cell behavior. Interestingly, the signaling molecules, that neutrophilic granulocytes use to communicate with each other, are poorly characterized.
The goal of this project is to assess how neutrophils produce and release these signaling molecules, which receptors are engaged on the neutrophil surface,
and which biological effects certain signaling molecules have in neutrophil biology. Additionally, we will investigate interactions between neutrophils and
other cells of the immune system, such as B- and T-cells.
Prospectively, the project can be extended to encompass the interactions between neutrophils and tumor cells, particularly melanoma cells, as neutrophils appear to play a pivotal role in tumor immunology.
We have a strong focus on microscopy (including life-cell imaging, confocal microscopy, and reflection interference microscopy), physical methods, such as atomic
force microscopy (AFM), as well as nanotechnology-based methods to detect signaling molecules in real time and at a very high spatial and temporal resolution.
Cell culture techniques, working with primary human cells and patient samples, as well as murine models will also be part of this project.
Settled at the interface of immunology, medicine, and biophysics, this project will be supervised by Dr. Luise Erpenbeck, MD (Dpt. of Dermatology, Venereology and Allergology),
in cooperation with Dr. Sebastian Kruss, PhD (Institute for Physical Chemistry, Göttingen, homepage:
www.uni-goettingen.de/de/512667.html). Dr. Erpenbeck’s research focuses on innate immunity in inflammatory diseases,
while Dr. Kruss has a long-standing interest in biophysical aspects of cellular behavior and nanothechnology.
The student will be enrolled in one of the GGNB graduate programs (Molecular Medicine, Neurobiology or Physics of Complex Biological Systems).
the possibility to work on an interdisciplinary, cutting-edge project
two well-equipped, modern laboratories with state of the art technology
a highly motivated research team
motivation to solve complex biological problems
a strong interest in learning new methods from different disciplines
the ability, to think outside the box and to combine results from different fields
Master's or Diploma in Biology, Physics, Biophysics, Biochemistry or a similar discipline
Men are especially encouraged to apply. Applicants with disabilities and equal qualifications will be given preferential treatment.
We look forward to receiving your application by February 28th, 2019:
University Medical Center Göttingen
Clinic for Dermatology, Venereology and Allergology
Dr. med. Luise Erpenbeck
Please send your application only via e-mail as a PDF file.
Travel and application fees cannot be refunded or transferred.
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