The Schlisio laboratory is offering a creative and international environment. We are part of the Department of Microbiology, Tumour And Cell Biology, MTC at the Karolinska Institute in Stockholm, Sweden, one of the world’s leading medical universities. The Ludwig Institute for Cancer Research is integrated at the Karolinska Institute.
Ludwig Cancer Research is a global community of leading scientists pursuing innovative ways to prevent and control cancer. From basic research to clinical trials, in individual laboratories or as part of international teams, our researchers are tackling the hardest questions, spotting the connections and the possibilities. At Ludwig, we test our work against the one measure that matters — improving human health.
Entgeltgruppe full time
Karolinska Institutet, Department of Microbiology, Tumor and Cell Biology: Oxygen Sensing and Cancer Group
The Schlisio lab at Karolinska Institute and Ludwig Institute, Sweden, seeks postdoctoral fellows, to work on molecular mechanisms of oxygen sensing and cancer. Our research concerns the mechanisms of how disruption of oxygen-sensing pathways can lead to cancer. Oxygen sensors enable the cell to adapt to low-oxygen environments and are critical for normal development and apoptosis. These events are often disrupted in the development of tumors. Oxygen sensing is mediated partly via prolyl hydroxylases that require molecular oxygen for enzymatic activity. Our work focuses on how prolyl hydroxylases execute apoptosis in neural precursors during development and how disruption of this process can lead to certain forms of nervous-system tumors.
We are seeking a motivated, creative post-doctoral candidate interested in tumor mouse models arising from the sympatho-adrenal lineage, such as neuroblastoma and pheochromocytoma, with the aim to understand the molecular principles of these tumors at a previously unprecedented level. Furthermore, we are looking for motivated, creative post-doctoral candidates interested in cancer metabolism with knowledge in basic biochemistry and molecular biology. We currently defining how oxygen sensing regulates mitochondrial dynamics and mass. In addition, we are looking for one outstanding researcher to work on the computational analyses of a large-scale single-cell transcriptome project on neuroblastoma. In this project we will generate “molecular encyclopedias” of this tumor in order to understand the molecular principles concerning the origin, progression and subtypes of this tumor at a previously unprecedented level, using state-of-the-art RNA-seq and bioinformatics technologies. Therefore, we seek one postdoctoral research fellow with expertise in computational analyses of RNA-seq data and OMICS data.
Position-specific requirements: The postdoctoral fellow in computational analyses of single-cell RNA-seq data should have a strong background in genome-wide bioinformatics, programming and linux environment. Previous experience with RNA-seq data analyses is required and additional experience with single-cell data, post-transcriptional gene regulation (e.g. splicing) or machine learning is a strong merit.
A person is eligible for a position as postdoctoral research fellow if he or she has obtained a PhD no more than seven years before the last date of employment as postdoc. Successful applicants must have the ability to work both independently and collaboratively in a group and have good English communication skills. Location: Dept MTC, Karolinska Institutet.
An employment application must contain the following documents in English: A complete curriculum vitae, including date of the thesis defense, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work
1. A CV including complete list of publications
2. A summary of current work (no more than one page) and your research interests
3. 2 reference letters
Send application to:
Associate Professor Susanne Schlisio
Ludwig Cancer Research
Karolinska Institute – MTC
Box 240, Nobels vag 3
SE-171 77 Stockholm
GENESDEV/2017/publish online 21th of June
Neuroblast differentiation during development and in neuroblastoma requires KIF1Bβ mediated transport of TRKA Stuart M Fell, Shuijie M. Li, Karin Wallis, Anna Kock, Olga Surova, Vilma Rraklli, Carolin S. Höfig, Wenyu Li, Jens Mittag, Marie Arsenian Henriksson, Rajappa S Kenchappa, Johan Holmberg, Per Kogner, and Susanne Schlisio.
The 1p36 Tumor Suppressor KIF 1Bβ Is Required for Calcineurin Activation, Controlling Mitochondrial Fission and Apoptosis Li S, Fell Sm, Surova O, Smedler E, Wallis K, Chen Zx, et al Developmental cell 2016;36(2):164-78
RNA helicase A is a downstream mediator of KIF1Bβ tumor-suppressor function in neuroblastoma Chen Zx, Wallis K, Fell Sm, Sobrado Vr, Hemmer Mc, Ramsköld D, et al Cancer discovery 2014;4(4):434-51 E-Mail: Susanne.Schlisio@ki.se
Department of Microbiology, Tumour And Cell Biology, MTC and Ludwig Cancer Research