Postdoctoral Position in Experimental
Hematology: Epigenetic Mechanisms in
Acute Myeloid Leukemia

Baldus laboratory, Medical Clinic II/Hematology and Oncology – Director: Prof. Dr. med. Claudia Baldus

The University Medical Center Schleswig-Holstein is one of the largest university hospitals in Europe with more than 80 clinics and institutes. It offers outstanding medical treatment and excellence in research and education with nearly 13,000 employees, 2,600 patient beds and more than 100,000 hospitalized patients, 240,000 outpatient cases and in excess of 3,000 births a year. We provide top research at the interface of medicine, science and technology. We are looking for competent support to join our interdisciplinary research group (Baldus laboratory) in Kiel which focuses on the genetic makeup and functional regulations in acute leukemias. The preferred starting date is as soon as possible. Your role:

• Within a project funded by the Deutsche José Carreras Leukämie-Stiftung (IDH mutations drive leukemogenesis by oncogenic activation due to insulator dysfunction), you will dissect aberrant epigenetic regulations in Acute Myeloid Leukemia.
• Using cell line models and primary samples, you will analyze the impact of frequently occurring mutations in isocitrate dehydrogenase (IDH) on long distance chromatin interactions and delineate oncogenic signaling as the result of altered DNA conformations.
• You will be part of a multidisciplinary research group of clinical and basic science investigators working within national consortia to elucidate leukemogenic mechanisms and to develop target-specific therapies for acute leukemia patients.
• Within this comprehensive translational approach, we combine preclinical leukemia models and human studies.

Your profile:

• You are an enthusiastic postdoctoral researcher (m/f) with a doctoral degree (PhD/Dr. rer. nat.) in biology, biochemistry, genetics or a related field.
• We expect experience in cell biological and molecular genetic techniques – preferentially in the context of cancer research or immunology.
• Experience in CRISPR/Cas9 genome editing, in NGS library preparation and in the analysis of high-dimensional data sets (PLAC-Seq, RNA-Seq, DNA methylation profiling) is appreciated, but can also be acquired in the research group.
• Good communication skills in English are essential, while proficiency in German is not a prerequisite.
• You are a focused individual with a strong work ethic, ready to independently acquire relevant background knowledge and skills and engage in cooperative work within the group and with the other consortia members.

What we offer:

• This is a fixed-term position for 3 years, with the possibility of extension.
• Weekly working time is 100% of a full-time position; working part-time is possible.
• Salary will be, depending on qualifications, according to the German salary scale 13 TV-L.

The UKSH has been certified as a family-friendly institution and is committed to further improving the compatibility of work and family life. The University Medical Center Schleswig-Holstein is an equal opportunity employer. People with disabilities will be given preference in case of equal qualifications. Does that sound interesting? For more details on the position, please contact Prof. Dr. Claudia Baldus (phone: +49(0)431 500-22500) or Dr. Lorenz Bastian (phone: +49(0)431 500-22526). More information on the University Medical Center Schleswig-Holstein and the Medical Clinic II can be obtained online at www.uksh.de/karriere and www.uksh.de/med2-kiel. We are looking forward to your application. Please submit your application until 31 January 2019, indicating your earliest possible starting date as well as the reference number 20180930, via our online portal: www.uksh.de/Bewerbung.html?nr=20180930 Universitätsklinikum Schleswig-Holstein
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