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The National Center for Tumor Diseases (NCT) was founded by the German Cancer Research Center (DKFZ), the University Clinic Carl Gustav Carus Dresden, the Medical Faculty of the TU Dresden and the Helmholtz-Zentrum Dresden-Rossendorf. With its research sites in Dresden and Heidelberg, the NCT is the leading oncology center in Germany and plans to develop into a top center internationally that is committed to individualized, patient-side cancer medicine. The successful candidate will be employed through the TU Dresden and work at the University Clinic Dresden in the framework of an ERA PreMed Grant, where he/she will be part of a newly establish NCT junior group that is located in the Department of Pediatrics at the University Clinic Dresden (Leader: Prof. Dr. Julia Hauer). The research focus of our team is in oncology/immunology with a special interest in inherited predispositions to pediatric cancer with a particular attention on childhood leukemias.
At the next possible point of time we would like to recruit a
This full-time-employment is limited for 25 month. The Position is according to the TV-L conditions (E13, 100 %)
Since 2019 we have implemented a trio-sequencing study that collects next generation sequencing data of child-parent trios of children newly diagnosed with cancer at our hospital. The here offered position revolves around processing and analyzing this data and its comparison to other available in-house and external datasets.
A pilot study, which has been ongoing in Düsseldorf, Germany, since 2016, has already shown the power and effectiveness of a trio-sequencing approach in regard to the identification of new cancer predisposing genes in childhood. The goal of this study is to not only extend the knowledge of pediatric cancer predisposition, but also to systematically depict its involvement in childhood cancers by incorporating new approaches like multigenic inheritance scenarios (e.g. one mutation that is inherited from the mother and one from the father). Functional validation of the results will be performed in the wet-lab, by a team of biologists that are specialized in elucidating the significance of variants of unknown significance (VUS) in-vitro and in-vivo.
The initial contract is set to a 2 year period, with extension potential.
For this position, we are looking for a PhD with either a background in bioinformatics or profound knowledge in data analysis, preferably with experience in working with large-scale whole genome/exome datasets as well as mutational analyses. The ideal candidate is tech-savvy, detail-oriented and diligent, with a general interest in cancer research, while he/she is friendly and open to work in a young and energetic research Group.
PhD or equivalent in bioinformatics or biology/biosciences (with strong bioinformatics background)
Highly motivated and enthusiastic for research focused work
Independent and structured work with good work ethics
Good English writing and communication skills, German knowledge advantageous but not necessary
Access to large, primary patient sequencing datasets
Strong connection between dry- and wet-lab
Interesting work environment with „state of the art“ techniques
Friendly and open minded team
International work environment through multiple European and international collaborations (travelling activities)
flexible working hours and various opportunities to reconcile work and private life
Good training opportunities
Severely disabled persons are explicitly encouraged to apply.
In order to apply, please submit a single pdf file until December, 04th 2019 with Registration number KIK0919881, that includes your CV, relevant certificates/degrees, a brief summary of your previous scientific experience and a short statement why you chose to apply for this position.