The Mildred Scheel Nachwuchszentrum (MSNZ) for Cancer Research in Würzburg (https://www.med.uni-wuerzburg.de/msnz) connects life scientists and clinicians to investigate mechanisms of tumor development and to develop new and innovative therapeutic strategies. Together with the Department of Biochemistry and Molecular Biology (https://www.biozentrum.uniwuerzburg.de/molbio/startseite/), our newly founded center is looking for enthusiastic who are interested to pursue PhD projects or postdoctoral work in one of the following groups. Armin Wiegering works on colorectal cancer with the aim to identify potential new therapeutic options, focusing on the control of protein translation in these tumors. Carolin Kastner works on colorectal liver metastasis. The planned project aims to identify factors necessary to coordinate transcription with DNA replication and prevent conflicts of both processes in highly proliferative tumor tissues. Gabriele Büchel works on neuroblastoma. The aim of her project is to establish new in vivo models of neuroblastoma, which will be used to test therapeutic strategies that target proteins of the MYCN interactome. Martin Eilers will study the MYCN oncoprotein, which drives the genesis of many pediatric and adult neuroendocrine tumors. The aim of the project is to identify protein complexes of MYCN that are critical for tumor maintenance and explore ways to target them. Elmar Wolf will establish systems for acute depletion of MYCassociated proteins to investigate their oncogenic role and validate them as drug targets. For example, we will explore novel pharmaceutical strategies such as PROTACs to inhibit their oncogenic function. Applications can be submitted until December 31st 2020. Projects shall start in spring 2021 (the exact starting times can be negotiated). We offer:
The recruiting groups work at the Biocenter of the University of Würzburg with fully equipped and modern laboratories, state-of-theart technology, competitive funding and access to core facilities.

• PhD students will be enrolled in the Graduate School of Life Science with broad research and skills training
• Close collaborations are established within the Mildred Scheel Nachwuchszentrum and the Biocenter, with the Comprehensive Cancer Centre, the University Hospital, the Rudolf Virchow Center and the Max Planck Institute for Systems Immunology in Würzburg
• Würzburg is a thriving place with local recreation areas and student-friendly vibes.

We welcome applications from suitably qualified people regardless of race, gender or disability. The University and the University Hospital aim to increase the proportion of female employees, therefore applications from qualified women are particularly welcome. Preference will be given to people with disabilities in the case of otherwise equal aptitude. Working language is English, knowledge of the German language can be beneficial, but is not required. If you would like to hear more about the projects please get in touch with the relevant Group Leader. Please send applications including a cover letter (with a statement of motivation), CV, relevant certificates and academic transcripts as well as contact information of two references as a single PDF file via email to Dr. Martin Czolbe
MSNZ/IZKF
Josef-Schneider-Str. 2
97080 Würzburg
Germany
+49 931 201-56439
czolbe_m@ukw.de
www.ukw.de