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Postdoc (m/f) at the Hertie Institute for Clinical Brain Research and Institute of Physiology

Universitätsklinikum Tübingen (UKT). Tübingen, 27.12.2017

Das Universitätsklinikum Tübingen ist eines der führenden Zentren der deutschen Hoch­schulmedizin. Es bietet medizinische Leistungen auf höchstem Niveau und deckt das gesamte Spektrum moderner Medizin auch in Forschung und Lehre ab.
Postdoctoral and PhD student positions available at the University of Tübingen – Hertie Institute for Clinical Brain Research and Institute of Physiology
Pathophysiology of genetic epilepsies during brain development
We are looking for motivated and highly skilled

Postdoctoral (100 %) and PhD (65 %)

candidates for the newly funded DFG Research Unit 2715 "Epileptogenesis of genetic epilepsies". We offer positions for 3 years, starting as soon as possible.
Our research groups have a long-standing experience in studying genetic and pathophysiological mechanisms underlying neuronal hyperexcitability and network dysfunction. We identified and functionally characterized several new epilepsy genes on the single cell and network level (e.g. Schubert et al. Nat Genet 2014; Syrbe, Hedrich et al. Nat Genet 2015; Hedrich et al. J Neurosci 2014; Wolf et al. Brain 2017) and analyzed in vivo physiological and pathological network oscillations (e.g. Adelsberger et al. Nat Neurosci 2005; Busche et al. Science 2008; Maier et al. Nat Med 2014).
The Projects:
The newly established Research Unit will focus on the mechanisms underlying epileptogenesis in genetic epilepsy syndromes. We seek to unravel (i) the genetic mechanisms of rare epileptic encephalopathies and common genetic generalized epilepsies, (ii) brain region-specific epileptogenesis in conditional mouse models using specific viral activation, and (iii) specific mechanisms of epileptogenesis during brain development. We will utilize a variety of techniques including next generation sequencing, molecular biology, single cell and network electrophysiology, large scale and high resolution in vivo calcium imaging and EEG recordings.
PhD candidates are embedded in our established Graduate School (Graduate Training Centre of Neuroscience) which will be complemented by specific modules covering important aspects of the genetics and pathophysiology of epilepsies.
We are looking for highly motivated and qualified researchers interested in the mechanisms of genetic epilepsies. The positions require either a PhD degree (for postdoc candidates) or a Master in Biology / Medicine or a related discipline (e. g. Molecular Biology, Molecular Medicine, Physics), ideally with a focus on neuroscience. Skills in genetics (next generation sequencing analysis), molecular biology, electrophysiology (patch clamp, EEG recordings) or calcium imaging are highly encouraged. More details can be found under and "­ (postdoc candidates). Women and people with disabilities are given preference for the same suitability.
How to apply:
The positions will be open until we find appropriate candidates. Please send your application including a letter of motivation, CV, list of publications, copies of certificates and the names of at least two references as a single PDF file to:
Prof. Dr. Holger Lerche
Dept. Neurology and Epileptology University of Tübingen
Hoppe-Seyler-Str. 3
72076 Tübingen, Germany
Prof. Dr. O. Garaschuk
Institute of Physiology University of Tübingen
Keplerstr. 15
72074 Tübingen, Germany
E-Mail: (PostDoc candidates only)
We offer remuneration in accordance with TV-L (collective wage agreement
for the Public Service of the German Federal States) in addition to all the
customary benefits granted to employees working in Public Services.
Severely handicapped persons with equal qualifications are given
preferential consideration. The University of Tübingen is anxious to increase
its quota of female scientific staff, and therefore emphatically requests
women to apply for this position. The Administration of the University
Hospital is responsible for all employment matters. Personnel appointments
will be made pursuant to the fundamental stipulations of the legal statutes
for universities in Germany. Interview expenses are not covered. Logo