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PhD Student Molecular Immunology (f/m/d)
The University Hospital Heidelberg is one of the major healthcare centers in Germany. Our objective is the development of innovative diagnostics and therapies as well as their quick implementation for the patient. With about 10,700 employees in more than 50 specialized clinical departments with almost 2,000 beds, about 80,000 patients in part-time and full-time inpatient treatment as well as 1,000,000 patients in ambulant treatment are medicated each year.
PhD Student Molecular Immunology (m/f/d)
Searched for the Institute of Immunology – Section Molecular Immunology.
The research group (head: Prof. Dr. Yvonne Samstag) investigates molecular mechanisms that control the activation and motility of immune cells in physiological and pathophysiological settings. As part of the SFB interdisciplinary collaborative research centre CRC156 ("The skin as sensor and effector organ orchestrating local and systemic immune responses"), the PhD project (CRC156-B04) aims to reveal new insights into influencing immune cell activation in allergy and chronic inflammatory skin diseases (e.g. allergic contact dermatitis and psoriasis). Particularly, it will focus on investigating and modulating the molecular mechanisms regulating the interaction between primary human keratinocytes and T cells, including application of an in vitro human skin equivalent model. Moreover, the role of actin-remodeling proteins for the function of different immune cells and their potential as therapeutic target will be analyzed by making use of knock-in and knock-out mouse models.
The aim of the project is to better understand the molecular mechanisms of inflammatory skin diseases and to identify potential therapeutic targets. The work will include a variety of biomedical and immunological research methods (e.g. in vivo mouse models, flow cytometry, confocal microscopy, biochemistry, cell biology, and molecular biology), that are largely established in the research group. The opportunity to shape the project with own ideas and to start developing an independent scientific profile will be given and encouraged.
design, implementation, and conductance of the project-related lab work (e.g. 2D in vitro coculture system, human skin equivalent models, immunohistochemistry, immunofluorescence, multi-color flow microscopy, mouse experiments)
communication with collaborating research groups of the CRC156
M. Sc. degree in the field of biology or related
basic knowledge of cell and molecular biology is required
hands-on experience with primary cells is preferable
experience in multi-color flow cytometry is preferable
experience in working with laboratory animals is preferable
high degree of motivation, enthusiasm in research, very good organizational skills
excellent English language skills
an exciting project in an international research group and collaborative environment
state-of-the-art research facilities
support for your personal and career development through internal training programs at Heidelberg University, individual supervision, and participation in conferences
The University Hospital Heidelberg offers:
individual, target-oriented advanced training ticket for public transport nursey and kindergarten as well as holiday organization for schoolchildren health promotion university sports / library
We stand for equal opportunities. People with disabilities are given priority with the same suitability. The university hospital aims at a general increase in the proportion of women in all areas and positions where women are underrepresented. Qualified women are therefore particularly encouraged to apply.